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Glucose & Diabetes

Hemoglobin A1c (HbA1c)

Normal range 4–5.6 % (20–38 mmol/mol SI). Specimen: Whole blood (EDTA).

Also known as: glycated hemoglobin, A1c, glycosylated hemoglobin.

4–5.6 %Reference range

Reference range

Conventional%
45.6
SImmol/mol
2038
SpecimenWhole blood (EDTA)
Conventional range4–5.6 %
SI range20–38 mmol/mol
PanelGlucose & Diabetes

What is the normal range for Hemoglobin A1c (HbA1c)?

The standard teaching reference range for Hemoglobin A1c (HbA1c) is 4–5.6 % in conventional units, or 20–38 mmol/mol in SI units. This value is measured in whole blood (edta).

Source: Adult reference values compiled from Pagana & Pagana, Mosby's Diagnostic and Laboratory Test Reference, and Fischbach & Dunning, A Manual of Laboratory and Diagnostic Tests. Reference ranges vary by laboratory, method, age, sex, and population — always use the range printed on the actual result.

Above the range

Common causes of a high Hemoglobin A1c (HbA1c)

  • Diabetes (poor long-term control)
  • Iron-deficiency anemia (falsely high)

Below the range

Common causes of a low Hemoglobin A1c (HbA1c)

  • Hemolysis or recent blood loss
  • Hemoglobinopathies
  • Pregnancy

At the bedside

Nursing considerations

  • Reflects average glucose over ~2–3 months; ≥ 6.5% supports diabetes.
  • Most diabetes treatment goals target < 7%.
  • Unreliable with hemoglobinopathies or altered red-cell survival.

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Your notes on Hemoglobin A1c (HbA1c)

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