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What is the normal range for PaCO₂ (Arterial CO₂)?
The standard teaching reference range for PaCO₂ (Arterial CO₂) is 35–45 mm Hg in conventional units, or 4.7–6 kPa in SI units. This value is measured in arterial blood.
A commonly taught critical (panic) value is < 20 or > 60 mm Hg. Critical results are reported to the provider immediately under your facility's policy.
Source: Adult reference values compiled from Pagana & Pagana, Mosby's Diagnostic and Laboratory Test Reference, and Fischbach & Dunning, A Manual of Laboratory and Diagnostic Tests. Reference ranges vary by laboratory, method, age, sex, and population — always use the range printed on the actual result.
Above the range
Common causes of a high PaCO₂ (Arterial CO₂)
Hypoventilation (respiratory acidosis)
COPD
Sedation / respiratory depression
Below the range
Common causes of a low PaCO₂ (Arterial CO₂)
Hyperventilation (respiratory alkalosis)
Anxiety
Compensation for metabolic acidosis
At the bedside
Nursing considerations
The respiratory component of acid–base balance.
Rising PaCO₂ with a falling pH signals ventilatory failure.