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Therapeutic Drug Levels

Carbamazepine Level

Normal range 4–12 µg/mL (17–51 µmol/L SI). Specimen: Serum (trough).

Also known as: Tegretol level.

4–12 µg/mLCritical: read below

Reference range

Conventionalµg/mL
412
SIµmol/L
1751
SpecimenSerum (trough)
Conventional range4–12 µg/mL
SI range17–51 µmol/L
Conversion factor×4.23 (conventional → SI)
Critical value> 12–15 µg/mL (ataxia, diplopia, drowsiness)
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What is the normal range for Carbamazepine Level?

The standard teaching reference range for Carbamazepine Level is 4–12 µg/mL in conventional units, or 17–51 µmol/L in SI units. This value is measured in serum (trough).

A commonly taught critical (panic) value is > 12–15 µg/mL (ataxia, diplopia, drowsiness). Critical results are reported to the provider immediately under your facility's policy.

Source: Adult reference values compiled from Pagana & Pagana, Mosby's Diagnostic and Laboratory Test Reference, and Fischbach & Dunning, A Manual of Laboratory and Diagnostic Tests. Reference ranges vary by laboratory, method, age, sex, and population — always use the range printed on the actual result.

Above the range

Common causes of a high Carbamazepine Level

  • Excess dosing
  • Drug interactions

Below the range

Common causes of a low Carbamazepine Level

  • Autoinduction of metabolism
  • Nonadherence

At the bedside

Nursing considerations

  • Monitor the CBC and sodium — carbamazepine can cause agranulocytosis and hyponatremia.

Study aid

Your notes on Carbamazepine Level

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