Convert any Phenytoin Level result between units on the unit converter.
What is the normal range for Phenytoin Level?
The standard teaching reference range for Phenytoin Level is 10–20 µg/mL in conventional units, or 40–79 µmol/L in SI units. This value is measured in serum (trough).
A commonly taught critical (panic) value is > 20 µg/mL (nystagmus, ataxia); > 30 confusion. Critical results are reported to the provider immediately under your facility's policy.
Source: Adult reference values compiled from Pagana & Pagana, Mosby's Diagnostic and Laboratory Test Reference, and Fischbach & Dunning, A Manual of Laboratory and Diagnostic Tests. Reference ranges vary by laboratory, method, age, sex, and population — always use the range printed on the actual result.
Above the range
Common causes of a high Phenytoin Level
Excess dosing
Liver disease
Drug interactions
Low albumin (raises free fraction)
Below the range
Common causes of a low Phenytoin Level
Nonadherence
Enzyme-inducing drugs
At the bedside
Nursing considerations
Toxicity progresses from nystagmus to ataxia to lethargy as levels climb.
Correct the measured level for low albumin, or measure free phenytoin.