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Therapeutic Drug Levels

Lithium Level

Normal range 0.6–1.2 mEq/L (0.6–1.2 mmol/L SI). Specimen: Serum (trough, 12 h post-dose).

Also known as: serum lithium.

0.6–1.2 mEq/LCritical: read below

Reference range

ConventionalmEq/L
0.61.2
SImmol/L
0.61.2
SpecimenSerum (trough, 12 h post-dose)
Conventional range0.6–1.2 mEq/L
SI range0.6–1.2 mmol/L
Conversion factor×1 (conventional → SI)
Critical value> 1.5 mEq/L is toxic; > 2.0 is a medical emergency
PanelTherapeutic Drug Levels

Convert any Lithium Level result between units on the unit converter.

What is the normal range for Lithium Level?

The standard teaching reference range for Lithium Level is 0.6–1.2 mEq/L in conventional units, or 0.6–1.2 mmol/L in SI units. This value is measured in serum (trough, 12 h post-dose).

A commonly taught critical (panic) value is > 1.5 mEq/L is toxic; > 2.0 is a medical emergency. Critical results are reported to the provider immediately under your facility's policy.

Source: Adult reference values compiled from Pagana & Pagana, Mosby's Diagnostic and Laboratory Test Reference, and Fischbach & Dunning, A Manual of Laboratory and Diagnostic Tests. Reference ranges vary by laboratory, method, age, sex, and population — always use the range printed on the actual result.

Above the range

Common causes of a high Lithium Level

  • Dehydration or sodium depletion
  • Renal impairment
  • NSAID or thiazide interaction
  • Overdose

Below the range

Common causes of a low Lithium Level

  • Subtherapeutic dosing
  • High sodium intake

At the bedside

Nursing considerations

  • Watch for tremor, GI upset, ataxia, and confusion as toxicity develops.
  • Maintain steady sodium and fluid intake — dehydration raises lithium.
  • Draw a true 12-hour trough before the morning dose.

Study aid

Your notes on Lithium Level

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