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Therapeutic Drug Levels

Digoxin Level

Normal range 0.8–2 ng/mL (1–2.6 nmol/L SI). Specimen: Serum (trough, ≥ 6 h post-dose).

Also known as: Lanoxin level.

0.8–2 ng/mLCritical: read below

Reference range

Conventionalng/mL
0.82
SInmol/L
12.6
SpecimenSerum (trough, ≥ 6 h post-dose)
Conventional range0.8–2 ng/mL
SI range1–2.6 nmol/L
Conversion factor×1.281 (conventional → SI)
Critical value> 2.0 ng/mL is toxic (many target 0.5–0.9 in heart failure)
PanelTherapeutic Drug Levels

Convert any Digoxin Level result between units on the unit converter.

What is the normal range for Digoxin Level?

The standard teaching reference range for Digoxin Level is 0.8–2 ng/mL in conventional units, or 1–2.6 nmol/L in SI units. This value is measured in serum (trough, ≥ 6 h post-dose).

A commonly taught critical (panic) value is > 2.0 ng/mL is toxic (many target 0.5–0.9 in heart failure). Critical results are reported to the provider immediately under your facility's policy.

Source: Adult reference values compiled from Pagana & Pagana, Mosby's Diagnostic and Laboratory Test Reference, and Fischbach & Dunning, A Manual of Laboratory and Diagnostic Tests. Reference ranges vary by laboratory, method, age, sex, and population — always use the range printed on the actual result.

Above the range

Common causes of a high Digoxin Level

  • Renal impairment
  • Hypokalemia (potentiates toxicity)
  • Drug interactions (amiodarone, verapamil)
  • Overdose

Below the range

Common causes of a low Digoxin Level

  • Subtherapeutic dosing
  • Malabsorption

At the bedside

Nursing considerations

  • Hold the dose and check for nausea, visual halos, and bradycardia when toxic.
  • Hypokalemia and hypomagnesemia worsen digoxin toxicity — monitor electrolytes.
  • Digoxin immune Fab is the antidote for severe toxicity.

Study aid

Your notes on Digoxin Level

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