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Therapeutic Drug Levels

Valproic Acid Level

Normal range 50–100 µg/mL (347–693 µmol/L SI). Specimen: Serum (trough).

Also known as: Depakote level, valproate.

50–100 µg/mLCritical: read below

Reference range

Conventionalµg/mL
50100
SIµmol/L
347693
SpecimenSerum (trough)
Conventional range50–100 µg/mL
SI range347–693 µmol/L
Conversion factor×6.93 (conventional → SI)
Critical value> 100–150 µg/mL (sedation, tremor)
PanelTherapeutic Drug Levels

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What is the normal range for Valproic Acid Level?

The standard teaching reference range for Valproic Acid Level is 50–100 µg/mL in conventional units, or 347–693 µmol/L in SI units. This value is measured in serum (trough).

A commonly taught critical (panic) value is > 100–150 µg/mL (sedation, tremor). Critical results are reported to the provider immediately under your facility's policy.

Source: Adult reference values compiled from Pagana & Pagana, Mosby's Diagnostic and Laboratory Test Reference, and Fischbach & Dunning, A Manual of Laboratory and Diagnostic Tests. Reference ranges vary by laboratory, method, age, sex, and population — always use the range printed on the actual result.

Above the range

Common causes of a high Valproic Acid Level

  • Excess dosing
  • Liver disease
  • Drug interactions

Below the range

Common causes of a low Valproic Acid Level

  • Nonadherence
  • Enzyme induction

At the bedside

Nursing considerations

  • Monitor liver function, ammonia, and platelets; valproate can cause hepatotoxicity and thrombocytopenia.

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