Therapeutic Drug Levels

Vancomycin Trough

Normal range 10–20 µg/mL (7–14 µmol/L SI). Specimen: Serum (trough, just before next dose).

Also known as: vanco trough.

10–20 µg/mLCritical: read below

Reference range

Conventionalµg/mL

1020

SIµmol/L

714

Specimen	Serum (trough, just before next dose)
Conventional range	10–20 µg/mL
SI range	7–14 µmol/L
Conversion factor	×0.69 (conventional → SI)
Critical value	> 20 µg/mL raises nephrotoxicity risk
Panel	Therapeutic Drug Levels

Convert any Vancomycin Trough result between units on the unit converter.

What is the normal range for Vancomycin Trough?

The standard teaching reference range for Vancomycin Trough is 10–20 µg/mL in conventional units, or 7–14 µmol/L in SI units. This value is measured in serum (trough, just before next dose).

A commonly taught critical (panic) value is > 20 µg/mL raises nephrotoxicity risk. Critical results are reported to the provider immediately under your facility's policy.

Source: Adult reference values compiled from Pagana & Pagana, Mosby's Diagnostic and Laboratory Test Reference, and Fischbach & Dunning, A Manual of Laboratory and Diagnostic Tests. Reference ranges vary by laboratory, method, age, sex, and population — always use the range printed on the actual result.

Above the range

Common causes of a high Vancomycin Trough

Renal impairment
Excess dosing
Concurrent nephrotoxins

Below the range

Common causes of a low Vancomycin Trough

Underdosing
Increased clearance

At the bedside

Nursing considerations

Draw the trough immediately before the next dose.
Monitor renal function; serious infections often target a trough of 15–20 (or AUC-guided dosing).

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